重组蛋白RecombinantMouseFc-gammaRI

描述Recombinant Mouse Fc-gamma RIII/CD16 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Ala31-Thr215) of mouse Fc γ RIIIA/FCGR3/CD16 (Accession #P08508) fused with a 6×His tag at the C-terminus.

靶点背景信息

Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Igsuperfamily. Based on close relati***hips in their extracellular domains, the Fc gamma Rs have been dividedinto three classes com***ing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Eachgroup may be encoded by multiple genes and exist in different isoforms depending on species and cell type.Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like domains c***isting ofimmunoglobulin domain, repeat, signa and transmembrane, transmembrane helix. It is expressed on a varietyof myeloid and lymphoid cells and associates with Fc R gamma to deliver an activating signal upon ligandbinding. Fcgr3 is IgG binding and activation or inhibition of immune resp***es such as antibody-dependentcellular cytotoxicity, phagocytosis, cell surface receptor signaling pathway and ***itive regulation of typeI/IIa/III hypersensitivity.

Swiss ProtP08508别名Low affinity immunoglobulin gamma Fc region receptor III; Fcgr3; Fc gamma Receptor III; CD-antigen 16; CD16; FcRIII; IgG Fc receptor III

文献引用

shrub is required for spermatogenesis of Drosophila melanogaster

PMID:

33660341